SIRT1 and Mental deterioration: Increased inhibition of electron transport chain complexes (NDUFC2, SHDC, COX10) compromises mitochondrial function and ATP formation leading to neuronal cell death; Increased SIRT1 and PTPA inhibition promotes tau hyperphosphorylation; Increased NR2A inhibition on post-synaptic membranes compromises synaptic plasticity impairing working memory; Increased VAMP2 and SYT1 inhibition on pre-synaptic membranes compromises vesicle exo/endocytosis; Increased inhibition of ADAM10 promotes intraneural accumulation of Aβ and rapid cognitive decline