BDNF and Alzheimer disease: Weinstein et al. (2014) found that in older adults, the risk for AD decreased by 33% for every increase in BDNF levels by one standard deviation increment. In parallel, the treatment of Tg2576 mice by a miR-206 antagomir restored brain levels of BDNF with direct improvements in hippocampal synaptic density and memory function (Lee et al., 2012).