Specifically, our research group has reported that a reduction in IGF-I levels in aging or APP/PS1 animal models of Alzheimer's disease induced an improvement in the neuronal activity in different brain areas (Zegarra-Valdivia et al., 2019, 2021; Garcia-Magro et al., 2022). This evidence concerns the gene IGF1 and early-onset autosomal dominant Alzheimer disease.