Another example of deregulation of gene expression is the case of miR-15a and miR-16-1, these are found at low levels of expression in mononuclear cells in the blood of patients with MS; Likewise, these miRNAs are found in T lymphocytes (CD4+) and also have effects on the B-cell lymphoma 2 gene (Bcl-2) in these lymphocytes, which delays apoptosis. The gene discussed is CD4; the disease is myeloid sarcoma.