Moreover, TDP-43 acts as a regulator of itself to reduce its expression levels in the cell, it binds to the 3′ UTR region of its own pre-mRNA and prevents its maturation and subsequent translation, a mechanism that can be seen altered in ALS since the autoregulatory capacity of TDP-43 does not exist or it is diminished (Koehler et al., 2022). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.