TARDBP and amyotrophic lateral sclerosis: In ALS, TDP-43 deposits are also present, OLs death is observed along the course of the disease, combined with high rates of defective OPCs proliferation (Philips et al., 2013), and since the simple removal of the TDP-43 protein from the nucleus of OLs is not enough to cause damage to the MN and NMJ, which is a necessary feature in ALS, additional abnormal processes must be involved.