Other miRNAs (miR-143-3p, −574-5p, and -133b) have been reported to be overexpressed during ALS disease, which correlated with the presence of TDP-43 clusters in the cytoplasm, which favored the metabolism of miRNAs by the Drosha and Dicer complex (Koehler et al., 2022). Here, DROSHA is linked to amyotrophic lateral sclerosis.