OlLs in the ALS pathology were not considered to play a relevant part in de onset and/or development of the disease until 2013 when TDP-43-positive aggregates in neurons and OLs in spinal cord samples from patients were reported; they also described abundant degenerative changes in OLs (Table 1; Philips et al., 2013; Pons et al., 2020). Here, TARDBP is linked to amyotrophic lateral sclerosis.