TARDBP and amyotrophic lateral sclerosis: Initially, only MNs in ALS were known to present abnormal TDP-43 deposits, but recently, pathological aggregation of TDP-43 has been described in other cell types too, OLs being one of them; RBPs aggregation, as mentioned before, is a feature found in both ALS and MS OLs but, for some reason, the fate of these cells is very different in each pathology.