TARDBP and amyotrophic lateral sclerosis: A growing number of molecular components associated with ALS have been identified, which includes the formation of protein aggregates; such as fused in sarcoma protein (FUS), deoxyribonucleic acid binding proteins such as TAR DNA-binding protein 43 (TDP-43), optineurin (OPTN), and the presence of a hexanucleotide repeat expansion in the C9orf72 gene or mutations of the superoxide dismutase 1 (SOD1) gene (Berdyński et al., 2022; Suzuki et al., 2023).