The correlation between 5 key DEPs (KRAS, INSR, CDK6, RPS6 and PCK1), 5 key mutant gene (KRAS, CCND1, PTEN, MTOR and TP53) and 14 functional states (occurrence, metastasis, treatment etc.)of CRC (Supplementary Figure 7A) were analyzed. This evidence concerns the gene TP53 and colorectal carcinoma.