The correlation between 5 key DEPs (KRAS, INSR, CDK6, RPS6 and PCK1), 5 key mutant gene (KRAS, CCND1, PTEN, MTOR and TP53) and 14 functional states (occurrence, metastasis, treatment etc.)of CRC (Supplementary Figure 7A) were analyzed. The gene discussed is INSR; the disease is colorectal carcinoma.