Although we have observed in vivo that GH improves remission of inflammation and mucosal repair during recovery in a colitis model (24), our finding supporting a role for GH in reprogramming GM-MØ metabolism is based on in vitro assays, and therefore might be considered reductionist, as monocyte/macrophage activity and their functional commitment are strongly conditioned by the surrounding environmental and by metabolic input. The gene discussed is GH1; the disease is colitis.