Additional studies examining individuals with PG and its syndromic form PG, acne, and suppurative hidradenitis (PASH) have identified mutations in components involved in regulation of innate immune responses (NLRP3, NLRP12, MEVF, NOD2, PSTPIP1), implicating dysregulated molecular pattern recognition signaling (15, 16). Here, PSTPIP1 is linked to acne.