This is due to miR-199a binding to the 3′UTR of silent information regulator 1 (SIRT1) mRNA inhibiting the anti-inflammatory effect of alveolar macrophages; MiR-107 induced tumor necrosis factor-α (TNF-α) secretion in endothelial cells by targeting dual specificity phosphatase 7 (DUSP7), which led to renal tubular cell injury during sepsis in mice and resulted in AKI (Wang et al., 2017). This evidence concerns the gene TNF and acute kidney injury.