MiR-146a binds to the 3′UTR of the mRNA of tumor necrosis factor receptor-associated factor 6 (TRAF6) and interleukin-1 receptor-associated kinase 1 (IRAK1) to inhibit gene expression of TRAF6 and IRAK1, thereby negatively regulating the TLR/NF-kB pathway and alleviating sepsis-induced cardiac dysfunction in mice (Gao et al., 2015). Here, IRAK1 is linked to Sepsis.