ERG and aneurysm: Integrating the scRNA-seq data with GWAS, the authors identified eleven differentially expressed genes associated with aneurysms including TWIST1, ADAM15, ERG, UBE2Q1, TPM3, ATP8B2, C1orf43, RSAD2, DNM2, KANK2, and HAX1. Notably, decreased expression of the transcription factor ERG, and mitochondrial dysfunction were observed in various cell types within TAA tissues.