The behavior of all these three genes, together with other genes involved in ECM structure and turnover (e.g., ADAM12, MMP1, TIMP3, COL3A1, COL1A2, PLOD2), is consistent with the enhanced TGF-β activity and the authors suggested their role in contributing to TAA development in MFS patients [124]. Here, TGFB1 is linked to Marfan syndrome.