GAS6-CAR-T cells effectively killed the high TAM-expressing mouse hepatoma carcinoma Hepa1-6 and breast cancer 4 T-1 cell lines (Fig. 7A, B) and induced the secretion of IFN-γ (Fig. 7C) and TNF-α (Fig. 7D), while GAS6-CAR-T cells displayed no significant toxicity or induction of cytokine release when exposed to the mouse embryonic fibroblast cell line NIH 3T3, which display low levels of TAM proteins (Fig. 7A–D). The gene discussed is TNF; the disease is breast cancer.