GAS6 and neoplasm: Furthermore, while large numbers of CD3 + T cells clustered in the tumor tissues of mice receiving GAS6-CAR-T cells, minimal numbers were observed in the major organs (Additional file 1: Fig. S9A), and no significant tissue damage or structural changes were observed in the major organs (heart, liver, spleen, lung, kidney, and brain) at day 5 or 42 of PANC1 xenograft (Additional file 1: Fig. S9B and Fig. 7G), and PDX model (Fig. 7H) after T-cell treatment in either group.