The human origin of cells in tumor was determined by immunohistochemistry analysis with a commercially available antibody specific for the human mitochondrial marker COX IV [27], and the tumor weight was significantly reduced at day 5 after GAS6-CAR-T cells infusion (Fig. 5D), and increase in CD3 + T-cell infiltration in mice receiving GAS6-CAR-T cells compared to Mock-treated mice (Fig. 5E). Here, COX4I1 is linked to neoplasm.