In this study, we generate CAR-T cells based on GAS6 and demonstrate that these GAS6-CAR-T cells can recognize all the TAM members, efficiently kill pancreatic cancer cells, and inhibit the growth of tumor xenografts without causing any overt side effects in mice even when the CAR-T is demonstrated to recognize mouse TAM and efficiently lyse mouse tumor cells. The gene discussed is GAS6; the disease is pancreatic neoplasm.