TNF and breast carcinoma: GAS6-CAR-T cells effectively killed the high TAM-expressing mouse hepatoma carcinoma Hepa1-6 and breast cancer 4 T-1 cell lines (Fig. 7A, B) and induced the secretion of IFN-γ (Fig. 7C) and TNF-α (Fig. 7D), while GAS6-CAR-T cells displayed no significant toxicity or induction of cytokine release when exposed to the mouse embryonic fibroblast cell line NIH 3T3, which display low levels of TAM proteins (Fig. 7A–D).