Indeed, we highlighted three pan-cancer NFκB/TNF hallmark genes (EGR1, JUNB, and ZNF36) [28–30] and identified four candidates (SRGN, CCN2, TNFRSF12A, and ZFP36L1) that are highly potentially involved in NFκB/TNF pathways in various cancers [31–40]. The gene discussed is TNFRSF12A; the disease is cancer.