The CA19-9, CEA, CYFRA21-1, and NSE in the NSCLC group were significantly higher than those in the BPD group (P < 0.05), and there was no significant difference in CA12-5 and SCC between the two groups (P > 0.05) (Supplementary Fig. 5). The gene discussed is ENO2; the disease is non-small cell lung carcinoma.