Moreover, we assessed the relationship between the different TME phenotypes and ccRCC patient survival, clinical features and treatment response.<h4>Results</h4>We found that ccRCC tissues had higher levels of CD8<sup>+</sup> T cells, CD163<sup>-</sup> macrophages, Treg cells, endothelial cells, and fibroblasts than paracancerous tissues. The gene discussed is CD8A; the disease is nonpapillary renal cell carcinoma.