In I/R induced kidney injury, to understand the involvement of ELF4 and whether this influences were related to OS and ERS, we assessed the change of OS index (SOD, CAT, and GSH-PX), OS related proteins (Nrf2, HO-1, and NQO-1), and ERS related proteins (GRP78, CHOP, and caspase-12). This evidence concerns the gene HSPA5 and urogenital neoplasm.