EDN1 and coronary artery disorder: CHD leads to increased blood flow to the pulmonary circulation that results in vascular dilation, endothelial damage, shear stress, impairment in the production of vasodilators such as NO endothelin-1 and prostacyclin, and activation of remodeling pathway that results in smooth muscle hypertrophy and fibrosis due to activation of fibroblasts [26].