In conclusion, thirteen characteristic modules and 49 susceptible hub genes for CAD&RA were identified by network modularization analysis, including ADO, ABCA11P, GALC, ZNF141, GPATCH8, ATF6, MIA3, etc. These hub genes and their corresponding molecular functions may reflect the underlying mechanism of CAD&RA, which can provide novel perspectives for their clinical therapy strategies and precise drug discovery. Here, ADO is linked to rheumatoid arthritis.