Seven out of these 49 hub genes had a GS greater than 0.6 and MM greater than 0.9, i.e., POT1, ADO, ABCA11P, GALC, ZNF141, GPATCH8 and ATF6. Compared to the known CAD and RA-related genes, 9, 2 and 485 genes were found between CAD-related and hub genes, RA-related and hub genes, CAD-related and RA-related genes, respectively (Fig. 5A). This evidence concerns the gene POT1 and coronary artery disorder.