Although the relationship among the poly(I:C)-induced inflammatory response, NMN treatment, and the expression level of EIF4B has not yet been determined, it is worth noting that EIF4B plays an important role in translation initiation together with EIF4A, and EIF4B is regulated by two major proto-oncogenic signaling pathways, Ras-MAPK and PI3-K/mTOR, which are important targets for cancer treatment24. The gene discussed is EIF4B; the disease is cancer.