Indeed, EHD1 overexpression was shown to promote cancer stem cell-like traits in glioblastoma and lung cancer by promoting CD44 recycling while suppressing its degradation15,70, promote cisplatin resistance in NSCLC by regulating cisplatin accumulation in cells presumably by regulating transporter levels9, and potentiate angiogenesis by promoting b2 adrenergic receptor recycling13. This evidence concerns the gene CD44 and cancer.