EHD1 and neoplasm: This idea is consistent with recent findings of EHD1 overexpression in various cancers, often correlating with shorter survival, and the cell-based studies using gene knockdown or overexpression strategies that support the role of EHD1 overexpression to promote tumorigenesis, chemotherapy resistance, epithelial-mesenchymal transition, stem cell behavior, and glycolysis in various tumor models6–15.