Morphometric analysis of tibial bone by micro-CT scanning showed reduced bone volume, trabecular number, thickness, and separation in mice implanted with NTC or mEHD1-rescued TC71 cells, indicative of increased tumor-induced bone degradation, with a significant amelioration of these defects in tibias of mice implanted with EHD1-KO cells (Fig. 3e, f). Here, EHD1 is linked to neoplasm.