IK14800 re-invigorates murine-derived exhausted CD4+ T cells obtained from a non-tumour murine model and when taken together with lack of in vitro cytotoxicity displayed by IK14800 at a ten-fold higher peptide concentration in B16F10 melanoma cell cultures than achievable in vivo, this lends support to the notion that IK14800 suppresses melanoma progression via immunomodulation. The gene discussed is CD4; the disease is melanoma.