Specifically, HPV− HNSCC tumors often present with PIK3CA, TP53, and CDKN2A alterations [13], while HPV+ HNSCC tumors have been shown to exhibit PIK3CA, TRAF3, CYLD, and E2F1 alterations [2, 15]. The gene discussed is TRAF3; the disease is head and neck squamous cell carcinoma.