For example, N-glycans on both alpha-1-acid glycoprotein (ORM1) (N56, N4H5S2) and immunoglobulin A heavy constant A1/2 (IGHA1;IGHA2) (N144/131, N5H3) as well as an O-glycan on alpha-2-HS-glycoprotein (AHSG) (S346, N1H1S1) show an increase above protein-level changes as COVID-19 severity increases (P < 0.01, Kendall trend test, Fig. 5e and Extended Data Fig. 6c). The gene discussed is ORM1; the disease is COVID-19.