Moreover, analysis of genes related to cholesterol uptake and synthesis in TCGA-GBM showed lower sterol regulatory element-binding protein 2 (SREBP2) expression for cholesterol synthesis, but higher epidermal growth factor receptor (EGFR) and LDLR expression for cholesterol uptake in GBM compared to normal brain tissue (Fig. 1g). The gene discussed is SREBF2; the disease is glioblastoma.