This was evident from the higher expression of EGFR, which facilitates exogenous cholesterol uptake through LDLR, and the lower expression of SREBP2, a cholesterol sensor that regulates cholesterol synthesis via 3-hydroxy-3-methylglutaryl-coA reductase (HMGCR), in GBM tumor tissue compared to normal brain tissue6,48. This evidence concerns the gene HMGCR and glioblastoma.