These showed that an ADCC-deficient humanized anti-GDF-15 antibody significantly enhanced the number of tumor-infiltrating CD45+ cells (p = 0.0374) and the proportion of CD3+ T cells in the infiltrate (p = 0.0106), while CD19+ (p = 0.3087) cells included as a less LFA-1-sensitive cell population were not increased (Fig. 4l, two independent experiments with a total of 9 mice per group). Here, GDF15 is linked to neoplasm.