The results indicated that the ATG5 mRNA and protein expression in Hep3B and Huh-7 cells was negatively correlated with the content of miR-205-5p in HCC cells, while this downregulation induced by miR-205-5p mimics could be reversed as a result of overexpression of circTGFBR2 (Fig. 6D, E). The gene discussed is ATG5; the disease is hepatocellular carcinoma.