KMT2A and myelodysplastic syndrome: Individuals with MDS were older than the remaining MLL cohort, with a bias towards males as previously reported32—the chance of having MDS in our cohort increased by 12% every year, with males being more than twice as likely to have MDS (p = 8 × 10−16 and p = 0.00017, respectively, for the binomial regression of MDS diagnosis based on age and sex; Fig. 1a, b; Table 1).