NPPB and atrial fibrillation: After comprehensive adjustment for EuroSCORE II, atrial fibrillation, ln(haemoglobin), LVEDD, Vpeak and aortic valve intervention (as time-dependant variable), continuous Nt-proBNP ratio and Nt-proBNP ratio ≥3 remained independently associated with increased mortality (respectively, 1.23 (95% CI 1.02 to 1.50), p=0.03; 1.26 (95% CI 1.05 to 1.51), p=0.01; table 2).