Consistent with these results, it was noteworthy that treatment of miR‐106b‐5p inhibitor transported by exosomes also resulted in a significant decrease in the number of F4/80‐positive macrophages (Figure 5D1–D3) and the mRNA levels of M1 macrophage markers, iNOS, TNF‐α, IL‐1β and CCL‐2 (Figure 5E), suggesting the weaken activation of pro‐inflammatory M1‐type polarization of macrophages in the AKI models. The gene discussed is IL1B; the disease is acute kidney injury.