Importantly, among the 18 genes selected by the reduced model, 8/18 genes (ANKRD22, APOL6, BATF2, DUSP3, FCGR1B, GBP4, GBP5, and VAMP5) were repeatedly identified by the best performing gene signature models for incipient TB diagnosis reported previously [43] (S4 Fig), in which DUSP3 and GBP5 were included in the Sweeney 3 gene signature and have been tested in a PoC setting for TB diagnosis [5,38,44]. Here, ANKRD22 is linked to tuberculosis.