A caucasian boy (ID M14CE762, Table 2) born to unaffected parents, manifested severe icterus, hepatosplenomegaly, and coagulopathy aged 2mo, with hyperbilirubinemia (total bilirubin 18x ULN, direct bilirubin 27.3x ULN), abnormal hepatobiliary-injury biomarker values (AST 8.9x ULN, ALT 2.8x ULN), and hypercholanemia (30x ULN). The gene discussed is GPT; the disease is blood coagulation disease.