For example, corticotropin-releasing hormone (receptor 1) antagonists have been shown to exacerbate subjective anxiety elicited by a social stressor (Trier Social Stress Task) and potentiate startle reactivity to certain-and-imminent shock delivery, despite evidence of reduced amygdala glucose metabolism and blunted amygdala reactivity to emotional faces [44, 120, 121]. The gene discussed is CRHR1; the disease is Anxiety.