To explore factors responsible for the downregulation of actin organization pathways in DD, HHD, and GD, we focused on 2 major known transcription factors that regulate genes involved in actin organization: serum response factor (SRF) and yes-associated protein/transcriptional coactivator with PDZ-binding motif (YAP/TAZ). The gene discussed is SRF; the disease is dentin dysplasia.