P2RY12 and Stroke: While DAPT reduced global platelet activation and aggregation in response to low-dose AYPGKF, adding aspirin to ticagrelor did not affect stroke outcomes in hPAR4Thr/Thr mice, indicating PAR4Thr/Thr-dependent platelet activation during stroke was not dependent on P2Y12 or COX-2 pathways.