To see whether CYP11B1 activity was inducible by inflammatory mediators, as it is in skin (16) and intestine (15), B16 (melanoma) or MC38 (colon carcinoma) cells were stimulated with cAMP, phorbol 12-myristate 13-acetate (PMA), LPS, TNF-α, or IL-6; all failed to induce CYP11B1 conversion of DOC to corticosterone (Supplemental Figure 1, C and D). The gene discussed is TNF; the disease is colon carcinoma.