Analysis of CD4+ and CD8+ TILs and other immune cell subsets found no difference in cell numbers between control and Hsd11b1–/– tumors, indicating that intratumor glucocorticoid signaling did not have a major effect on leukocyte trafficking into or expansion within the tumor (Supplemental Figure 4D), suggesting that their activity must be altered in the glucocorticoid-generating tumors. This evidence concerns the gene CD8A and neoplasm.