LIPA and fibrosis: In line with the importance of LAL enzyme, both Reiner et al. and Koranantakul et al. have reported that the lack of this enzyme leads to the accumulation of both CEs and TGs in different body organs causing several cellular damages such as in the liver (microvacuolar steatosis, increased transaminase levels, fibrosis, and cirrhosis), cardiovascular system, and spleen (splenomegaly), and gastrointestinal disturbances including diarrhea and abdominal pain are related to lipid accumulation in the intestinal mucosa (Reiner et al. 2014; Koranantakul et al. 2021; Patrick and Lake 1969).