LIPA and lysosomal storage disease: Lysosomal storage disorder is an inherited defect caused by the deficiency of lysosomal acid lipase (LAL) (NP_000226) and is characterized by an accumulation of cholesteryl esters (CEs) and triglycerides (TGs) in the lysosome (Maciejko 2017; Gomaraschi et al. 2018; Li and Zhang 2019; Pastores and Hughes 2020).