WD is a rare, autosomal recessive, and fatal disease caused by a significant reduction of LAL activity due to biallelic variations in the LIPA gene which is localized on chromosome 10q23.2q23.3, including 10 exons, 9 introns, and encodes (372 amino acid polypeptide) which necessary for secretion and lysosomal targeting of LAL enzyme (Maciejko 2017; Grabowski et al. 2021). This evidence concerns the gene LIPA and Wilson disease.