Methylated DNA in the PJ can also provide clinically relevant information to diagnose PDAC, and three methylated DNA markers (C13orf18, FER1L4, and BMP3) can distinguish non-PDAC patients from PDAC patients, including those in the early stage or those with HG IPMN [124]. Here, FER1L4 is linked to pancreatic intraductal papillary-mucinous neoplasm.