AFP and portal hypertension: An analysis of the large Italian ITA.LI.CA HCC registry classified tumours into either single aetiology MAFLD (S-MAFLD), mixed-aetiology MAFLD (M-MAFLD) or non-MAFLD, and found that S-MAFLD tumours were larger, more frequently associated with extrahepatic metastases, but less frequent clinically relevant portal hypertension or MELD score > 10 and with lower AFP compared with non-MAFLD tumours.