Considering that PTEN has been proved to be of guiding significance in predicting the prognosis of liver cancer [33], and in view of the heterogeneity of TME in the grouping of HCC cases expressed by PTEN, this study focused on the DEGs between the patients with high expression of PTEN and low expression of PTEN, and designed a multi-gene classification model to guide the prognosis prediction of HCC. Here, PTEN is linked to hepatocellular carcinoma.