Variable parameters such as serum AFP level, des-gamma-carboxy prothrombin level, tumor size and number, margin status, major vessel invasion, tumor stage, Edmonson-Steiner grade, Child–Pugh score, portal hypertension and cirrhosis, are regarded as clinical prognosticators of HCC, hinging on the treatment modalities and underling liver diseases [4]. The gene discussed is AFP; the disease is liver disorder.