PTEN and cancer: Phosphatase and tensin homologue (PTEN), which a tumor suppressor gene located in the long arm of chromosome 10 at position 23.3 that often manifests mutation in cancer, could suppress tumorigenesis via a variety of mechanisms, for example, subcellular localization and protein–protein interaction, phosphatase-dependent and independent activities, and it regulates many cellular functions including DNA repair and cell movement, cell growth, proliferation, and survival [9, 10].