In addition, the up-regulation of GZMB expression by histamine in Th2-polarized CD4+ T cells, in CD4+ cells activated by IL-4 or in CD4+ T cells from AD patients indicates that this mediator of allergic inflammation may play a role in the homeostasis of the expression of GMZB in atopy and allergy. The gene discussed is GZMB; the disease is Allergy.