BRCA1 recruits both PERK and IRE1, which suggests that BRCA1, PERK, and IRE1 could form a complex under ER stress; BRCA1 deficiency leads to the accumulation of PERK and IRE1, which constitutively activates UPR and promotes survival of BRCA1-deficient cancer cells. This evidence concerns the gene EIF2AK3 and cancer.