For example, the expression of genes involved in the IFN-I and IFNγ signaling pathways (e.g. ISG20 and IFITM1-3), TLR signaling pathway (e.g. TLR4 and TLR2) and response to TNF (e.g. TNFSF13B and TNFRSF14) was the highest in TBN and TB (Figure 3(b and c)). This evidence concerns the gene TLR4 and tuberculosis.