GPC1 and pancreatic ductal adenocarcinoma: As a case study of high clinical relevance, we demonstratean accurate and robust portable GFET array biosensor platform forthe detection of pancreatic ductal adenocarcinoma (PDAC) in patients’plasma through specific exosomes (GPC-1 expression) within 45 min.In order to facilitate reproducible detection in blood plasma, weoptimized the analytical performance of GFET biosensors via the applicationof an internal control channel and the development of an optimizedtest protocol.