Next, for the purpose of translating the mechanism of miR‐651‐5p and CALM2 in lung cancer, a series of assay were conducted with the results implying that miR‐651‐5p overexpression or CALM2 interference repressed the proliferative, migratory, and invasive behaviors of lung cancer cells and promoted apoptosis. The gene discussed is CALM2; the disease is lung carcinoma.