RBX1 and adenoma: To determine the nature of tumor suppression caused by Rbx1‐deletion, we utilized the immunohistochemical (IHC) staining analysis and found that in hyperplasia/adenomas tissues from LSL‐KrasG12D;Rbx1fl/fl mice, the staining/levels of Ki67 and pErk were significantly reduced, along with p4e‐bp1, although it did not reach the statistically significant level due to sample variations (Figure 1F).