IL6 and Alzheimer disease: Inflammation factor expression analysis showed that CD4, CSF1, CSF3, IFNA1, and IL1A were downregulated in AD, whereas HLA-DRB3, HLA-DRB4, IL10, IL15, IL5, IL6, PDGFA, and TGFB3 were upregulated (Supplementary Figure 1, C).