In addition, VDAC1 has a critical role in neuronal development and synapse formation, which implies that it is potentially involved in AD onset and progression (Marin et al., 2007; Cuadrado-Tejedor et al., 2011; Manczak and Reddy, 2012; Reddy, 2013; Smilansky et al., 2015). This evidence concerns the gene VDAC1 and Alzheimer disease.