In very rare cases, PLG, KNG1, ANGPT1, MYOF and HS3ST6 are suspected of being involved in nC1-INH HAE type pathogenesis (Bafunno et al., 2018; Bork et al., 2018; Dewald, 2018; Bork et al., 2019; Ariano et al., 2020; Bork et al., 2021), although further evidence is needed to approve their causal role, in particular, in the latter two. The gene discussed is ANGPT1; the disease is hereditary angioedema.