In HAE patients, CXCL8 level was only increased during attacks (Veszeli et al., 2015; Kajdácsi et al., 2021), but not in asymptomatic periods (Demirtürk et al., 2014; Grymová et al., 2019), which is consistent with non-inflammatory macrophages’ state between attacks. The gene discussed is CXCL8; the disease is hereditary angioedema.