GJB2 and cystic fibrosis: A similar effect was described for 3 (VRT-534), which is used to treat cystic fibrosis by specificallytargeting the G551D mutation.44 Althoughno related structure or mutation exists in Cx26, the binding of compoundswith moderate affinity using a repurposing strategy can help in furtheridentifying molecules exhibiting high affinity or be used for screeningsin molecular docking experiments.