Reduced eotaxin (CCL11) and elevated hepatocyte growth factor (HGF) were associated with an increased risk of epilepsy (OR = 1.904, 95% CI = 1.019–3.561, p = 0.044; OR = 0.641, 95% CI = 0.417–0.984, p = 0.042) when the IVW method was used. This evidence concerns the gene CCL11 and epilepsy.