Although elevated Interleukin-18 (IL-18) levels were associated with a decreased risk of epilepsy, the efficacy of the assessment may have been lower because the results were not significant (P > 0.05) when using the IVW method, thus necessitating the use of the MR-Egger method (OR = 0.482, 95% CI = 0.251–0.927, p = 0.046). This evidence concerns the gene IL18 and epilepsy.