It was found that the majority of m6A regulators was up-regulated in HCC except ZC3H13, including METTL3, METTL4, WTAP, VIRMA, RMB15B, YTHDC1, YTHDC2, YTHDF3, YTHDF1, YTDHF2, HNRNPC, IGF2BP1, IGF2BP2, IGF2BP3, RBMX, HNRNPA2B1, FTO, and ALKBHS (Figures 1A, B). The gene discussed is METTL3; the disease is hepatocellular carcinoma.