MAP2K7 and Alzheimer disease: Of note, MEK activation is implicated in AD pathogenesis, where MEK activation is significantly up-regulated leading to increased ERK activation in AD, and MEK inhibitors decrease Aβ plaque formation in SY5Y cells and 5XFAD AD mice models (Mills et al., 1997; Zhu et al., 2003; Araki et al., 2010; Chun et al., 2022).