In contrast to the MESCs study and our study, OGT KD in MDA-MB-231, MDA-MB-468, and MDA-MB-157 breast cancer cells increased SIRT1 levels and activity causing a reduction of MEK/ERK signaling, increased proteasomal degradation, and decreased activity of the oncogenic transcription factor FOXM1, and lowered invasion potential (Ferrer et al., 2017). This evidence concerns the gene FOXM1 and breast cancer.