In contrast to the MESCs study and our study, OGT KD in MDA-MB-231, MDA-MB-468, and MDA-MB-157 breast cancer cells increased SIRT1 levels and activity causing a reduction of MEK/ERK signaling, increased proteasomal degradation, and decreased activity of the oncogenic transcription factor FOXM1, and lowered invasion potential (Ferrer et al., 2017). The gene discussed is OGT; the disease is breast carcinoma.