S100A8 and hereditary elliptocytosis: In multivariate analyses, the baseline age (HR: 1.006; 95% confidence interval (CI): 1.002–1.011; and P=0.009), creatinine (HR: 1.005; 95% CI: 1.001–1.010; and P=0.019), INR (HR: 1.620; 95% CI: 1.227–2.138; and P=0.001), HE grade (HR: 1.330; 95% CI: 1.023–1.731; and P=0.034), S100A8 (HR: 1.027; 95% CI: 1.007–1.048; and P=0.026), and S100A9 (HR: 1.009; 95% CI: 1.001–1.017; and P=0.007) were significant independent predictors of 28-day mortality (Table 2).