Moreover, age (HR: 1.034; 95% CI: 1.007–1.061; and P=0.013), TB (HR: 1.002; 95% CI: 1.001–1.003; and P=0.002), HE grade (HR: 1.499; 95% CI: 1.173–1.916; and P=0.001), INR (HR: 2.362; 95% CI: 1.740–3.207; and P < 0.001), S100A8 (HR: 1.023; 95% CI: 1.011–1.035; and P=0.004), and S100A9 (HR: 1.008; 95% CI: 1.004–1.012; and P < 0.001) were significant independent predictors of 90-day mortality (Table 2). Here, S100A8 is linked to hereditary elliptocytosis.