Biomarkers that were discovered to correlate with the presence of a cancer field are loss of heterozygosity (LOH) (Tabor et al., 2001), micro-satellite alterations (Tabor et al., 2001), chromosomal instability (Hittelman, 2001), and mutations in the TP53 gene (Brennan et al., 1995; van Houten et al., 2002). Here, TP53 is linked to cancer.